2017

PDFStructure and energetics of pairwise interactions between proteasome subunits RPN2, RPN13, and ubiquitin clarify a substrate recruitment mechanism.
VanderLinden RT, Hemmis CW, Yao T, Robinson H, Hill CP
J Biol Chem. 2017 Apr 25. doi: 10.1074/jbc.M117.785287. PMID:28442575

PDFStructural basis of protein translocation by the Vps4-Vta1 AAA ATPase.
Monroe N, Han H, Shen PS, Sundquist WI, Hill CP
Elife. 2017 Apr 5;6. pii: e24487. doi: 10.7554/eLife.24487. PMID: 28379137

2016

PDFMeiotic Clade AAA ATPases: Protein Polymer Disassembly Machines.
Monroe N, Hill CP
J Mol Biol. 2016 May 8;428(9 Pt B):1897-911. doi: 10.1016 PMID:26555750

2015

PDFFACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs
Kemble DJ, McCullough LL, Whitby FG, Formosa T, Hill CP
Mol Cell. 2015 Oct 15;60(2):294-306

PDFEditorial overview: Macromolecular machines and assemblies: Rise and fall at the molecular level
Forest KT, Hill CP
Curr Opin Struct Biol. 2015 Apr;31:vii-viii.

PDFBinding of Substrates to the Central Pore of the Vps4 ATPase Is Autoinhibited by the Microtubule Interacting and Trafficking (MIT) Domain and Activated by MIT Interacting Motifs (MIMs)
Han H, Monroe N, Votteler J, Shakya B, Sundquist WI, Hill CP
J Biol Chem. 2015 May 22;290(21):13490-9

PDFStructural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase
VanderLinden RT, Hemmis CW, Schmidt B, Ndoja A, Whitby FG, Robinson H, Cohen RE, Yao T, Hill CP
Molecular Cell. 2015 57(5), March 5, 901-911

2014

PDFDesign and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets
Clinton TR, Weinstock MT, Jacobsen MT, Szabo-Fresnais N, Pandya MJ, Whitby FG, Herbert AS, Prugar LI, McKinnon R, Hill CP, Welch BD, Dye JM, Eckert DM, Kay MS.
Protein Sci. 2014 Oct 6 Supplemental 1

 

PDFThe Oligomeric State of the Active Vps4 AAA ATPase
Monroe N, Han H, Gonciarz MD, Eckert DM, Karren MA, Whitby FG, Sundquist WI, Hill CP
J. Mol. Biol 2014, 426(3) 510–525 Supplemental 1, Supplemental 2, Supplemental 3

2013

PDFBuilding a Super Elongation Complex for HIV
Hill CP & Sundquist WI.
eLife. eLife 2:e00327.doi: 10.7554/eLife.00327

PDFStructure of the Spt16 Middle Domain Reveals Functional Features of the Histone Chaperone FACT.
Kemble DJ, Whitby FG, Robinson H, McCullough LL, Formosa T, Hill CP.
J Biol Chem. (Epub ahead of print).

PDFStructural Biology of the Proteasome
Kish-Trier E, Hill CP.
Annu Rev Biophys. 2013 May 6;42:29-49. doi: 10.1146/annurev-biophys-083012-130417. Epub 2013 Feb 13

PDFStructure of an actin-related subcomplex of the SWI/SNF chromatin remodeler
Schubert HL, Wittmeyer J, Kasten MM, Hinata K, Rawling DC, Héroux A, Cairns BR, Hill CP.
PNAS 2013 Feb 26;110(9):3345-50

2012

PDF Structure of a Proteasome Pba1-Pba2 Complex: IMPLICATIONS FOR PROTEASOME ASSEMBLY, ACTIVATION, AND BIOLOGICAL FUNCTION.
Stadtmueller BM, Kish-Trier E, Ferrell K, Petersen CN, Robinson H, Myszka DG, Eckert DM, Formosa T, Hill CP.
J Biol Chem. 2012 Oct 26;287(44):37371-82 Epub 2012 Aug 28, PMCID: PMC3481334

PDF  Structure and function of the membrane deformation AAA ATPase Vps4.
Hill CP, Babst M.
Biochim Biophys Acta. 2012 Jan;1823(1):172-81. Epub 2011 Sep 8.

2011

PDF  An asymmetric interface between the regulatory and core particles of the proteasome.
Tian G, Park S, Lee MJ, Huck B, McAllister F, Hill CP, Gygi SP, Finley D.
Nat Struc Mtol Biol. 2011 Oct 30;18(11):1259-67. doi: 10.1038/nsmb.2147.  PMCID: PMC3210322  Supplemental

PDF  Activation of the retroviral budding factor ALIX.
Zhai Q, Landesman MB, Chung HY, Dierkers A, Jeffries CM, Trewhella J, Hill CP, Sundquist WI.
J Virol. 2011 Sep;85(17):9222-6. Epub 2011 Jun 29.    Supplemental

PDF  UNC119 is required for G protein trafficking in sensory neurons.
Zhang H, Constantine R, Vorobiev S, Chen Y, Seetharaman J, Huang YJ, Xiao R, Montelione GT, Gerstner CD, Davis MW, Inana G, Whitby FG, Jorgensen EM, Hill CP, Tong L, Baehr W.
Nat Neurosci. 2011 Jun 5;14(7):874-80. doi: 10.1038/nn.2835.    Supplemental

PDF  Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain.
Close D, Johnson SJ, Sdano MA, McDonald SM, Robinson H, Formosa T, Hill CP.
J Mol Biol. 2011 May 13;408(4):697-713. Epub 2011 Mar 17.    Supplemental

PDF  Proteasome activators.
Stadtmueller BM, Hill CP.
Mol Cell. 2011 Jan 7;41(1):8-19. Review.

PDF  Identification and structural characterization of the ALIX-binding late domains of simian immunodeficiency virus SIVmac239 and SIVagmTan-1.
Zhai Q, Landesman MB, Robinson H, Sundquist WI, Hill CP.
J Virol. 2011 Jan;85(1):632-7. Epub 2010 Oct 20.

PDF  Structure of the Bro1 domain protein BROX and functional analyses of the ALIX Bro1 domain in HIV-1 budding.
Zhai Q, Landesman MB, Robinson H, Sundquist WI, Hill CP.
PLoS One. 2011;6(12):e27466. Epub 2011 Dec 5.

2010

PDF  Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes.
Koirala S, Bui HT, Schubert HL, Eckert DM, Hill CP, Kay MS, Shaw JM.
J Cell Biol. 2010 Dec 13;191(6):1127-39.

PDF  Structure and biological importance of the Spn1-Spt6 interaction, and its regulatory role in nucleosome binding.
McDonald SM, Close D, Xin H, Formosa T, Hill CP.
Mol Cell. 2010 Dec 10;40(5):725-35. Epub 2010 Nov 25.    Supplemental

PDF  Design of a potent D-peptide HIV-1 entry inhibitor with a strong barrier to resistance.
Welch BD, Francis JN, Redman JS, Paul S, Weinstock MT, Reeves JD, Lie YS, Whitby FG, Eckert DM, Hill CP, Root MJ, Kay MS.
J Virol. 2010 Nov;84(21):11235-44. Epub 2010 Aug 18.

PDF  Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations.
Schubert HL, Zhai Q, Sandrin V, Eckert DM, Garcia-Maya M, Saul L, Sundquist WI, Steiner RA, Hill CP.
Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):17951-6. Epub 2010 Sep 29.    Supplemental

PDF  X-ray structures of isopentenyl phosphate kinase.
Mabanglo MF, Schubert HL, Chen M, Hill CP, Poulter CD.
ACS Chem Biol. 2010 May 21;5(5):517-27.

PDF  Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening.
Sadre-Bazzaz K, Whitby FG, Robinson H, Formosa T, Hill CP.
Mol Cell. 2010 Mar 12;37(5):728-35.    Supplemental

PDF  Emergent Properties of EWS/FLI Regulation via GGAA Microsatellites in Ewing's Sarcoma.
Gangwal K, Close D, Enriquez CA, Hill CP, Lessnick
SL. Genes Cancer. 2010 Feb 1;1(2):177-187.    Supplemental 1    Supplemental 2

PDF  Structural models for interactions between the 20S proteasome and its PAN/19S activators.
Stadtmueller BM, Ferrell K, Whitby FG, Heroux A, Robinson H, Myszka DG, Hill CP.
J Biol Chem. 2010 Jan 1;285(1):13-7. Epub 2009 Nov 4.

2009

PDF  Structural basis for ESCRT-III protein autoinhibition.
Bajorek M, Schubert HL, McCullough J, Langelier C, Eckert DM, Stubblefield WM, Uter NT, Myszka DG, Hill CP, Sundquist WI.
Nat Struct Mol Biol. 2009 Jul;16(7):754-62. Epub 2009 Jun 14.    Supplemental

PDF  X-ray structures of the hexameric building block of the HIV capsid.
Pornillos O, Ganser-Pornillos BK, Kelly BN, Hua Y, Whitby FG, Stout CD, Sundquist WI, Hill CP, Yeager M.
Cell. 2009 Jun 26;137(7):1282-92. Epub 2009 Jun 11.    Supplemental

PDF  Substrate shuttling between active sites of uroporphyrinogen decarboxylase is not required to generate coproporphyrinogen.
Phillips JD, Warby CA, Whitby FG, Kushner JP, Hill CP. J Mol Biol. 2009 Jun 5;389(2):306-14. Epub 2009 Apr 10.
J Mol Biol. 2009 Jun 5;389(2):306-14. Epub 2009 Apr 10.

2008

PDF  Biochemical and structural studies of yeast Vps4 oligomerization.
Gonciarz MD, Whitby FG, Eckert DM, Kieffer C, Heroux A, Sundquist WI, Hill CP.
J Mol Biol. 2008 Dec 26;384(4):878-95. Epub 2008 Oct 4.

PDF  Structure and function of SirC from Bacillus megaterium: a metal-binding precorrin-2 dehydrogenase.
Schubert HL, Rose RS, Leech HK, Brindley AA, Hill CP, Rigby SE, Warren MJ.
Biochem J. 2008 Oct 15;415(2):257-63.

PDF  Structure and mechanistic implications of a uroporphyrinogen III synthase-product complex.
Schubert HL, Phillips JD, Heroux A, Hill CP.
Biochemistry. 2008 Aug 19;47(33):8648-55. Epub 2008 Jul 24.

PDF  ALIX-CHMP4 interactions in the human ESCRT pathway.
McCullough J, Fisher RD, Whitby FG, Sundquist WI, Hill CP.
Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7687-91. Epub 2008 May 29.    Supplemental

PDF  Crystal structure and RNA binding of the Tex protein from Pseudomonas aeruginosa.
Johnson SJ, Close D, Robinson H, Vallet-Gely I, Dove SL, Hill CP.
J Mol Biol. 2008 Apr 11;377(5):1460-73. Epub 2008 Feb 12.    Supplemental

PDF  Cryo-EM structure of dodecameric Vps4p and its 2:1 complex with Vta1p.
Yu Z, Gonciarz MD, Sundquist WI, Hill CP, Jensen GJ.
J Mol Biol. 2008 Mar 21;377(2):364-77. Epub 2008 Jan 12.    Supplemental

PDF  Structural and functional analysis of the Spt16p N-terminal domain reveals overlapping roles of yFACT subunits.
VanDemark AP, Xin H, McCullough L, Rawlins R, Bentley S, Heroux A, Stillman DJ, Hill CP, Formosa T.
J Biol Chem. 2008 Feb 22;283(8):5058-68. Epub 2007 Dec 18.    Supplemental

2007

PDF  Potent D-peptide inhibitors of HIV-1 entry.
Welch BD, VanDemark AP, Heroux A, Hill CP, Kay MS.
Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16828-33. Epub 2007 Oct 17.    Supplemental

PDF  Structure of the antiviral assembly inhibitor CAP-1 complex with the HIV-1 CA protein.
Kelly BN, Kyere S, Kinde I, Tang C, Howard BR, Robinson H, Sundquist WI, Summers MF, Hill CP.
J Mol Biol. 2007 Oct 19;373(2):355-66. Epub 2007 Aug 15.    Supplemental

PDF  How to assemble a capsid.
Sundquist WI, Hill CP.
Cell. 2007 Oct 5;131(1):17-9.

PDF  Autoregulation of the rsc4 tandem bromodomain by gcn5 acetylation.
VanDemark AP, Kasten MM, Ferris E, Heroux A, Hill CP, Cairns BR.
Mol Cell. 2007 Sep 7;27(5):817-28.    Supplemental

PDF  Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding.
Fisher RD, Chung HY, Zhai Q, Robinson H, Sundquist WI, Hill CP.
Cell. 2007 Mar 9;128(5):841-52.    Supplemental

PDF  A versatile platform for inactivation and destruction.
Whitby FG, Hill CP.
Structure. 2007 Feb;15(2):137-8. No abstract available.

PDF  Two novel uroporphyrinogen decarboxylase (URO-D) mutations causing hepatoerythropoietic porphyria (HEP).
Phillips JD, Whitby FG, Stadtmueller BM, Edwards CQ, Hill CP, Kushner JP.
Transl Res. 2007 Feb;149(2):85-91.

2006

PDF  Structure of ATP-bound human ATP:cobalamin adenosyltransferase.
Schubert HL, Hill CP.
Biochemistry. 2006 Dec 26;45(51):15188-96.    Supplemental

PDF  Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain.
Alam SL, Langelier C, Whitby FG, Koirala S, Robinson H, Hill CP, Sundquist WI.
Nat Struct Mol Biol. 2006 Nov;13(11):1029-30. Epub 2006 Oct 22.    Supplemental: S1, S2, S3, S4, S5

PDF  Implications for viral capsid assembly from crystal structures of HIV-1 Gag(1-278) and CA(N)(133-278).
Kelly BN, Howard BR, Wang H, Robinson H, Sundquist WI, Hill CP.
Biochemistry. 2006 Sep 26;45(38):11257-66.

PDF  Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release.
Langelier C, von Schwedler UK, Fisher RD, De Domenico I, White PL, Hill CP, Kaplan J, Ward D, Sundquist WI.
J Virol. 2006 Oct;80(19):9465-80.    Supplemental

PDF  Structure of the Blm10-20 S proteasome complex by cryo-electron microscopy. Insights into the mechanism of activation of mature yeast proteasomes.
Iwanczyk J, Sadre-Bazzaz K, Ferrell K, Kondrashkina E, Formosa T, Hill CP, Ortega J.
J Mol Biol. 2006 Oct 27;363(3):648-59. Epub 2006 Aug 9.    Supplemental

PDF  The structure of the yFACT Pob3-M domain, its interaction with the DNA replication factor RPA, and a potential role in nucleosome deposition.
VanDemark AP, Blanksma M, Ferris E, Heroux A, Hill CP, Formosa T.
Mol Cell. 2006 May 5;22(3):363-74. Erratum in: Mol Cell. 2007 Jul 6;27(1):171-2.    Supplemental

2005

PDF  Purification and analysis of recombinant 11S activators of the 20S proteasome: Trypanosoma brucei PA26 and human PA28 alpha, PA28 beta, and PA28 gamma.
Masters EI, Pratt G, Förster A, Hill CP.
Methods Enzymol. 2005;398:306-21.

PDF  Structural and mechanistic studies of VPS4 proteins.
Scott A, Chung HY, Gonciarz-Swiatek M, Hill GC, Whitby FG, Gaspar J, Holton JM, Viswanathan R, Ghaffarian S, Hill CP, Sundquist WI.
EMBO J. 2005 Oct 19;24(20):3658-69. Epub 2005 Sep 29.    Supplemental

PDF  Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing.
Macbeth MR, Schubert HL, Vandemark AP, Lingam AT, Hill CP, Bass BL.
Science. 2005 Sep 2;309(5740):1534-9.    Supplemental

PDF  Ubiquitin-binding domains.
Hicke L, Schubert HL, Hill CP.
Nat Rev Mol Cell Biol. 2005 Aug;6(8):610-21. Review.

PDF  The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions.
Förster A, Masters EI, Whitby FG, Robinson H, Hill CP.
Mol Cell. 2005 May 27;18(5):589-99.    Supplemental

PDF  Crystal structure of the flagellar rotor protein FliN from Thermotoga maritima.
Brown PN, Mathews MA, Joss LA, Hill CP, Blair DF.
J Bacteriol. 2005 Apr;187(8):2890-902.

PDF  E1 on the move.
VanDemark AP, Hill CP.
Mol Cell. 2005 Feb 18;17(4):474-5. Review.

PDF  Mobilizing the proteolytic machine: cell biological roles of proteasome activators and inhibitors.
Rechsteiner M, Hill CP.
Trends Cell Biol. 2005 Jan;15(1):27-33. Review.

2004

PDF  Grabbing E2 by the tail.
VanDemark AP, Hill CP.
Nat Struct Mol Biol. 2004 Oct;11(10):908-9.

PDF  Crystal structure of the oxygen-dependant coproporphyrinogen oxidase (Hem13p) of Saccharomyces cerevisiae.
Phillips JD, Whitby FG, Warby CA, Labbe P, Yang C, Pflugrath JW, Ferrara JD, Robinson H, Kushner JP, Hill CP.
J Biol Chem. 2004 Sep 10;279(37):38960-8. Epub 2004 Jun 12.

PDF  Ubiquitin recognition by the human TSG101 protein.
Sundquist WI, Schubert HL, Kelly BN, Hill GC, Holton JM, Hill CP.
Mol Cell. 2004 Mar 26;13(6):783-9.    Supplemental

2003

PDF  Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase.
Phillips JD, Whitby FG, Kushner JP, Hill CP.
EMBO J. 2003 Dec 1;22(23):6225-33.

PDF  Proteasome degradation: enter the substrate.
Förster A, Hill CP.
Trends Cell Biol. 2003 Nov;13(11):550-3.

PDF  The pore of activated 20S proteasomes has an ordered 7-fold symmetric conformation.
Förster A, Whitby FG, Hill CP.
EMBO J. 2003 Sep 1;22(17):4356-64.    Supplemental

PDF  Structure and ubiquitin binding of the ubiquitin-interacting motif.
Fisher RD, Wang B, Alam SL, Higginson DS, Robinson H, Sundquist WI, Hill CP.
J Biol Chem. 2003 Aug 1;278(31):28976-84. Epub 2003 May 14.

PDF  Structures along the catalytic pathway of PrmC/HemK, an N5-glutamine AdoMet-dependent methyltransferase.
Schubert HL, Phillips JD, Hill CP.
Biochemistry. 2003 May 20;42(19):5592-9.

PDF  Structural insights into the catalytic mechanism of cyclophilin A.
Howard BR, Vajdos FF, Li S, Sundquist WI, Hill CP.
Nat Struct Biol. 2003 Jun;10(6):475-81.    Supplemental

PDF  Two-stepping with E1.
VanDemark AP, Hill CP.
Nat Struct Biol. 2003 Apr;10(4):244-6.

2002

PDF  Structural basis of ubiquitylation.
VanDemark AP, Hill CP.
Curr Opin Struct Biol. 2002 Dec;12(6):822-30. Review.

PDF  Structural diversity in metal ion chelation and the structure of uroporphyrinogen III synthase.
Schubert HL, Raux E, Matthews MA, Phillips JD, Wilson KS, Hill CP, Warren MJ.
Biochem Soc Trans. 2002 Aug;30(4):595-600. Review.

PDF  Crystal structure of the middle and C-terminal domains of the flagellar rotor protein FliG.
Brown PN, Hill CP, Blair DF.
EMBO J. 2002 Jul 1;21(13):3225-34.

PDF  Crystal structure of a biliverdin IXalpha reductase enzyme-cofactor complex.
Whitby FG, Phillips JD, Hill CP, McCoubrey W, Maines MD.
J Mol Biol. 2002 Jun 21;319(5):1199-210.

PDF  The structure of Saccharomyces cerevisiae Met8p, a bifunctional dehydrogenase and ferrochelatase.
Schubert HL, Raux E, Brindley AA, Leech HK, Wilson KS, Hill CP, Warren MJ.
EMBO J. 2002 May 1;21(9):2068-75.

PDF  SUMO wrestling with specificity.
VanDemark AP, Hill CP.
Structure. 2002 Mar;10(3):281-2.

The 11S regulators of 20S proteasome activity.
Hill CP, Masters EI, Whitby FG.
Curr Top Microbiol Immunol. 2002;268:73-89. Review.
[Reprint available upon request]

2001

PDF  Functional consequences of naturally occurring mutations in human uroporphyrinogen decarboxylase.
Phillips JD, Parker TL, Schubert HL, Whitby FG, Hill CP, Kushner JP.
Blood. 2001 Dec 1;98(12):3179-85.

PDF  Crystal structure of human uroporphyrinogen III synthase.
Mathews MA, Schubert HL, Whitby FG, Alexander KJ, Schadick K, Bergonia HA, Phillips JD, Hill CP.
EMBO J. 2001 Nov 1;20(21):5832-9.

PDF  Defining polyubiquitin chain topology.
Chan NL, Hill CP.
Nat Struct Biol. 2001 Aug;8(8):650-2. No abstract available.

PDF  Structure of a new crystal form of tetraubiquitin.
Phillips CL, Thrower J, Pickart CM, Hill CP.
Acta Crystallogr D Biol Crystallogr. 2001 Feb;57(Pt 2):341-4.

2000

PDF  Structural basis for the activation of 20S proteasomes by 11S regulators.
Whitby FG, Masters EI, Kramer L, Knowlton JR, Yao Y, Wang CC, Hill CP.
Nature. 2000 Nov 2;408(6808):115-20.

PDF  Image reconstructions of helical assemblies of the HIV-1 CA protein.
Li S, Hill CP, Sundquist WI, Finch JT.
Nature. 2000 Sep 21;407(6802):409-13.

1999

PDF  Structure of the C-terminal domain of FliG, a component of the rotor in the bacterial flagellar motor.
Lloyd SA, Whitby FG, Blair DF, Hill CP.
Nature. 1999 Jul 29;400(6743):472-5.

PDF  Structural basis for the specificity of ubiquitin C-terminal hydrolases.
Johnston SC, Riddle SM, Cohen RE, Hill CP.
EMBO J. 1999 Jul 15;18(14):3877-87.

PDF  Crystal structures of adenine phosphoribosyltransferase from Leishmania donovani.
Phillips CL, Ullman B, Brennan RG, Hill CP.
EMBO J. 1999 Jul 1;18(13):3533-45.

PDF  Structures of the HIV-1 capsid protein dimerization domain at 2.6 A resolution.
Worthylake DK, Wang H, Yoo S, Sundquist WI, Hill CP.
Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):85-92. Epub 1999 Jan 1.

1998

PDF  Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes.
Whitby FG, Xia G, Pickart CM, Hill CP.
J Biol Chem. 1998 Dec 25;273(52):34983-91.

PDF  Crystal structure of human uroporphyrinogen decarboxylase.
Whitby FG, Phillips JD, Kushner JP, Hill CP.
EMBO J. 1998 May 1;17(9):2463-71.

PDF  Identification of an activation region in the proteasome activator REGalpha.
Zhang Z, Clawson A, Realini C, Jensen CC, Knowlton JR, Hill CP, Rechsteiner M.
Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2807-11.

PDF  Crystal structure of the Saccharomyces cerevisiae ubiquitin-conjugating enzyme Rad6 at 2.6 A resolution.
Worthylake DK, Prakash S, Prakash L, Hill CP.
J Biol Chem. 1998 Mar 13;273(11):6271-6.

1997

PDF  Structure of the proteasome activator REGalpha (PA28alpha).
Knowlton JR, Johnston SC, Whitby FG, Realini C, Zhang Z, Rechsteiner M, Hill CP.
Nature. 1997 Dec 11;390(6660):639-43.

PDF  The proteasome 11S regulator subunit REG alpha (PA28 alpha) is a heptamer.
Johnston SC, Whitby FG, Realini C, Rechsteiner M, Hill CP.
Protein Sci. 1997 Nov;6(11):2469-73.

PDF  Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.
Vajdos FF, Yoo S, Houseweart M, Sundquist WI, Hill CP.
Protein Sci. 1997 Nov;6(11):2297-307.

PDF  Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein.
Gamble TR, Yoo S, Vajdos FF, von Schwedler UK, Worthylake DK, Wang H, McCutcheon JP, Sundquist WI, Hill CP.
Science. 1997 Oct 31;278(5339):849-53.

PDF  Characterization of recombinant REGalpha, REGbeta, and REGgamma proteasome activators.
Realini C, Jensen CC, Zhang Z, Johnston SC, Knowlton JR, Hill CP, Rechsteiner M.
J Biol Chem. 1997 Oct 10;272(41):25483-92.

PDF  Crystal structure of Tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex.
Whitby FG, Luecke H, Kuhn P, Somoza JR, Huete-Perez JA, Phillips JD, Hill CP, Fletterick RJ, Wang CC.
Biochemistry. 1997 Sep 2;36(35):10666-74.

PDF  Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution.
Johnston SC, Larsen CN, Cook WJ, Wilkinson KD, Hill CP.
EMBO J. 1997 Jul 1;16(13):3787-96.

PDF  Molecular recognition in the HIV-1 capsid/cyclophilin A complex.
Yoo S, Myszka DG, Yeh C, McMurray M, Hill CP, Sundquist WI.
J Mol Biol. 1997 Jun 27;269(5):780-95.

PDF  Structures of wild-type chloromet and L103N hydroxomet Themiste zostericola myohemerythrins at 1.8 A resolution.
Martins LJ, Hill CP, Ellis WR Jr.
Biochemistry. 1997 Jun 10;36(23):7044-9.

PDF  Characterization and crystallization of human uroporphyrinogen decarboxylase.
Phillips JD, Whitby FG, Kushner JP, Hill CP.
Protein Sci. 1997 Jun;6(6):1343-6.

1996

PDF  Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid.
Gamble TR, Vajdos FF, Yoo S, Worthylake DK, Houseweart M, Sundquist WI, Hill CP.
Cell. 1996 Dec 27;87(7):1285-94.

PDF  Comparison of the NMR and X-ray structures of the HIV-1 matrix protein: evidence for conformational changes during viral assembly.
Massiah MA, Worthylake D, Christensen AM, Sundquist WI, Hill CP, Summers MF.
Protein Sci. 1996 Dec;5(12):2391-8.

PDF  Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: implications for membrane association and assembly.
Hill CP, Worthylake D, Bancroft DP, Christensen AM, Sundquist WI.
Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3099-104.

1995

Penicillin acylase has a single-amino-acid catalytic centre.
Duggleby HJ, Tolley SP, Hill CP, Dodson EJ, Dodson G, Moody PC.
Nature. 1995 Jan 19;373(6511):264-8.

1993

PDF  The structure of granulocyte-colony-stimulating factor and its relationship to other growth factors.
Hill CP, Osslund TD, Eisenberg D.
Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5167-71.

PDF  Crystal structure of a ubiquitin-dependent degradation substrate: a three-disulfide form of lysozyme.
Hill CP, Johnston NL, Cohen RE.
Proc Natl Acad Sci U S A. 1993 May 1;90(9):4136-40.

Complex of ribonuclease from Streptomyces aureofaciens with 2'-GMP at 1.7 A resolution.
Sevcik J, Hill CP, Dauter Z, Wilson KS.
Acta Crystallogr D Biol Crystallogr. 1993 Mar 1;49(Pt 2):257-71.

1991

PDF  Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization.
Hill CP, Yee J, Selsted ME, Eisenberg D.
Science. 1991 Mar 22;251(5000):1481-5.

X-ray structure of an unusual Ca2+ site and the roles of Zn2+ and Ca2+ in the assembly, stability, and storage of the insulin hexamer.
Hill CP, Dauter Z, Dodson EJ, Dodson GG, Dunn MF.
Biochemistry. 1991 Jan 29;30(4):917-24.

1990

PDF  Crystal structure of alpha 1: implications for protein design.
Hill CP, Anderson DH, Wesson L, DeGrado WF, Eisenberg D.
Science. 1990 Aug 3;249(4968):543-6.

Expression, purification and crystallization of penicillin G acylase from Escherichia coli ATCC 11105.
Hunt PD, Tolley SP, Ward RJ, Hill CP, Dodson GG.
Protein Eng. 1990 Jul;3(7):635-9.

Pre-History

Protein crystallography: more surprises ahead.
Eisenberg D, Hill CP.
Trends Biochem Sci. Jul;14(7):260-4. Review. (1989)

Comparative Study of Microbial Ribonuclease Structures.
Hill, C.P.
Structure and Chemistry of Ribonucleases, A. Pavlovsky and K. Polyakov, eds, p. 171-179. (1989)

The 2-Zinc Insulin Hexamer is a Calcium Binding Protein.
Dunn, M.F., Palmieri, R., Kaarsholm, N.C., Roy, M., Lee, R.W.-K., Dauter, Z., Hill, C., Dodson, G.G.
Calcium Binding Proteins in Health and Disease, A.W. Norman, T.C. Vanamon and A. Means, eds., pp. 372-383 (1987)

The 2-Zinc Insulin Hexamer is a Calcium Binding Protein.
Dunn, M.F., Palmieri, R., Kaarsholm, N.C., Roy, M., Lee, R.W.-K., Dauter, Z., Hill, C., Dodson, G.G.
Calcium Binding Proteins in Health and Disease, A.W. Norman, T.C. Vanamon and A. Means, eds., pp. 372-383 (1987)

Structural Comparison of Some Microbial Ribonucleases.
Hill, C.P., Dodson, G.G., Borisova, S.N., Pavlovsky, A.G., Polyakov, K.M., Strokopytov, B.V. and Sevcik, J.
Metab. and Enzymology of Nucl. Acids 6:317-322 (1987)

The Structure and Catalytic Site of Microbial Ribonuclease.
Dodson, E.J., Dodson, G.G., Hill, C. and Mauguen, Y.
Metab. and Enzymology of Nucl. Acids 5:41-57 (1984)

The Structural and Sequence Homology of a Family of Microbial Ribonucleases.
Hill, C., Dodson, G., Heinemann, U., Saenger, W., Mitsui, Y., Nakamura, K., Borisov, S., Tischenko, G., Polyakov, K. and Pavlovsky, S.
Trends in Biochem. Sci. 8:364-369 (1983)