OVERVIEW | PROTEASOME | NUCLEOSOME | HIV | OTHER

Nucleosome Remodeling
and Reorganization

The packaging of DNA into nucleosomes provides a mechanism to compact and organize the ~1 meter-long chromosomes that exist in our cells. It also performs critical regulatory roles by controlling access to the DNA by transcription and replication factors and polymerases. In an effort to understand how access to nucleosome DNA is regulated, we are investigating nucleosome remodelers, which translocate DNA along nucleosomes (collaboration with Brad Cairns), and nucleosome reorganizing complexes, which alter the contacts between histones and DNA and can function as histone chaperones (collaboration with Tim Formosa).