HIV Biology

We have a long-standing interest in the architecture of the HIV virion, including the organization of the MA and CA proteins in the matrix shell and the cone-shaped capsid, respectively. We also aim to understand how HIV interacts with host cellular components in order to facilitate distinct steps in viral replication, including the mechanism of viral budding, which recruits the cellular ESCRT pathway. Most of this work is collaborative with Wes Sundquist and coordinated through the CHEETAH center. We also collaborate with Michael Kay to advance development of D-peptide inhibitors of viral entry.